Cajun Chicken Alfredo Fettuccine

Featured in: Savory Quick Bites

This dish combines tender chicken breasts rubbed in Cajun seasoning with fettuccine pasta coated in a rich, creamy Velveeta cheese sauce. Garlic and spices create depth, while a touch of cayenne adds warmth. The sauce blends heavy cream, butter, and Parmesan for smooth texture and balance. Served garnished with fresh parsley and extra cheese, it offers a comforting meal with Southern-inspired flavors. Quick to prepare with about 40 minutes total time, it's ideal for an easy, flavorful main course.

Updated on Sun, 23 Nov 2025 16:50:00 GMT
Steaming bowl of Cajun Chicken Alfredo Fettuccine pasta with juicy chicken and creamy, cheesy sauce. Save
Steaming bowl of Cajun Chicken Alfredo Fettuccine pasta with juicy chicken and creamy, cheesy sauce. | collationspot.com

A creamy, spicy pasta dish featuring tender Cajun-seasoned chicken, rich Velveeta cheese sauce, and perfectly cooked fettuccine—comfort food with a Southern twist.

This recipe quickly became a family favorite after I served it for a casual dinner; the rich sauce and Cajun seasoning are always a hit.

Ingredients

  • Chicken: 2 large boneless, skinless chicken breasts, 1 ½ tablespoons Cajun seasoning, 1 tablespoon olive oil
  • Pasta: 12 oz (340 g) fettuccine pasta
  • Sauce: 2 tablespoons unsalted butter, 2 cloves garlic minced, 1 cup (240 ml) heavy cream, 8 oz (225 g) Velveeta cheese cubed, ½ cup (50 g) grated Parmesan cheese, ½ teaspoon black pepper, ¼ teaspoon cayenne pepper (optional, for extra heat), Salt to taste
  • Garnish: 2 tablespoons fresh parsley chopped, Extra grated Parmesan cheese (optional)

Instructions

Step 1:
Bring a large pot of salted water to a boil. Cook the fettuccine according to package instructions until al dente. Drain and set aside, reserving ½ cup pasta water.
Step 2:
While the pasta cooks, pat chicken breasts dry. Rub both sides with Cajun seasoning.
Step 3:
In a large skillet, heat olive oil over medium-high heat. Add chicken and cook 5–6 minutes per side, or until golden and cooked through (internal temperature 165°F/74°C). Remove chicken, let rest 5 minutes, then slice thinly.
Step 4:
In the same skillet, reduce heat to medium. Add butter and garlic; sauté 1 minute until fragrant.
Step 5:
Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes, stirring often until melted and smooth.
Step 6:
Add Parmesan cheese, black pepper, and cayenne pepper (if using). Stir until fully combined and creamy. If sauce is too thick, add reserved pasta water a little at a time.
Step 7:
Toss cooked fettuccine in the sauce until well coated.
Step 8:
Divide pasta among plates. Top with sliced Cajun chicken. Garnish with parsley and extra Parmesan if desired.
Savor the flavors of this delicious Cajun Chicken Alfredo Fettuccine, perfectly garnished with parsley. Save
Savor the flavors of this delicious Cajun Chicken Alfredo Fettuccine, perfectly garnished with parsley. | collationspot.com

My family loves gathering around this dish on busy weeknights because it feels indulgent yet is simple enough to make quickly.

Notes

Add sautéed bell peppers or mushrooms to the sauce for extra flavor and color, and pair this dish with a crisp green salad and a chilled Chardonnay for a complete meal.

Required Tools

Large pot, large skillet, knife and cutting board, tongs or pasta fork, measuring cups and spoons

Allergen Information

Contains milk/dairy (Velveeta, Parmesan, cream, butter), contains wheat (fettuccine), and contains chicken. Those with allergies should check ingredient labels for hidden allergens.

A close-up of a plated Cajun Chicken Alfredo Fettuccine dish, enticingly rich with a spicy cheese sauce. Save
A close-up of a plated Cajun Chicken Alfredo Fettuccine dish, enticingly rich with a spicy cheese sauce. | collationspot.com

This Cajun Chicken Alfredo makes for a comforting, crowd-pleasing meal that you'll want to make again and again.

Recipe Help

How is the chicken prepared to ensure tenderness?

The chicken breasts are rubbed with Cajun seasoning and cooked in olive oil until golden and cooked through, then rested before slicing to retain juiciness.

What gives the sauce its creamy texture?

The sauce combines Velveeta cheese with heavy cream, butter, and Parmesan, stirred until smooth and creamy.

Can the spice level be adjusted?

Yes, cayenne pepper can be added or omitted to increase or reduce the heat according to taste preferences.

What is the best way to cook the fettuccine pasta?

Cook the fettuccine in salted boiling water until al dente, then drain while reserving some pasta water to adjust sauce consistency if needed.

Are there options to add extra vegetables?

Sautéed bell peppers or mushrooms can be added for additional flavor and color enhancements.

Cajun Chicken Alfredo Fettuccine

Spicy Cajun chicken paired with creamy Velveeta sauce and tender fettuccine for a comforting meal.

Prep Time
15 min
Time to Cook
25 min
Overall Time
40 min
Created by Chloe Martin


Skill Level Easy

Cuisine Type American (Cajun-inspired)

Makes 4 Portions

Special Diets None specified

What You’ll Need

Chicken

01 2 large boneless, skinless chicken breasts
02 1 ½ tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 oz fettuccine pasta

Sauce

01 2 tablespoons unsalted butter
02 2 cloves garlic, minced
03 1 cup heavy cream
04 8 oz Velveeta cheese, cubed
05 ½ cup grated Parmesan cheese
06 ½ teaspoon black pepper
07 ¼ teaspoon cayenne pepper (optional)
08 Salt, to taste

Garnish

01 2 tablespoons fresh parsley, chopped
02 Extra grated Parmesan cheese (optional)

How-To

Step 01

Cook fettuccine: Bring a large pot of salted water to a boil. Cook fettuccine until al dente according to package instructions. Drain, reserving ½ cup pasta water, and set aside.

Step 02

Prepare chicken: Pat chicken breasts dry and rub both sides evenly with Cajun seasoning.

Step 03

Sear chicken: Heat olive oil in a large skillet over medium-high heat. Cook chicken 5-6 minutes per side until golden and fully cooked (internal temperature 165°F). Remove from skillet and let rest for 5 minutes before slicing thinly.

Step 04

Sauté garlic: Reduce skillet heat to medium. Melt butter, then add minced garlic and sauté for 1 minute until fragrant.

Step 05

Prepare cheese sauce: Stir in heavy cream and bring to gentle simmer. Add Velveeta cheese cubes gradually, stirring frequently until melted and smooth.

Step 06

Season sauce: Incorporate grated Parmesan, black pepper, cayenne pepper if desired, and salt to taste. Adjust sauce thickness by adding reserved pasta water incrementally until desired consistency is achieved.

Step 07

Combine pasta and sauce: Toss cooked fettuccine in the Velveeta sauce, ensuring thorough coating.

Step 08

Serve: Plate pasta and top with sliced Cajun chicken. Garnish with chopped parsley and extra Parmesan cheese if preferred.

Gear Needed

  • Large pot
  • Large skillet
  • Knife and cutting board
  • Tongs or pasta fork
  • Measuring cups and spoons

Allergy Details

Review every item for allergens and connect with your healthcare provider if you’re unsure.
  • Contains milk/dairy (Velveeta, Parmesan, cream, butter)
  • Contains wheat (fettuccine pasta)
  • Contains poultry (chicken)

Nutrition Breakdown (each serving)

Info for reference only—don’t take this as expert medical guidance.
  • Caloric Value: 670
  • Lipids: 32 g
  • Carbohydrates: 57 g
  • Proteins: 41 g